Cancer cell metabolism: Warburg and beyond

Cell. 2008 Sep 5;134(5):703-7. doi: 10.1016/j.cell.2008.08.021.


Described decades ago, the Warburg effect of aerobic glycolysis is a key metabolic hallmark of cancer, yet its significance remains unclear. In this Essay, we re-examine the Warburg effect and establish a framework for understanding its contribution to the altered metabolism of cancer cells.

MeSH terms

  • Animals
  • Biosynthetic Pathways*
  • Cell Respiration
  • Energy Metabolism*
  • Glycolysis
  • Humans
  • Neoplasms / metabolism*