The multiple roles of phosphoinositide 3-kinase in mast cell biology

Trends Immunol. 2008 Oct;29(10):493-501. doi: 10.1016/j.it.2008.07.004. Epub 2008 Sep 3.

Abstract

Mast cells play a central role in the initiation of inflammatory responses associated with asthma and other allergic disorders. Receptor-mediated mast cell growth, differentiation, homing to their target tissues, survival and activation are all controlled, to varying degrees, by phosphoinositide-3-kinase (PI3K)-driven pathways. It is not fully understood how such diverse responses can be differentially regulated by PI3K. However, recent studies have provided greater insight into the mechanisms that control, and those that are controlled by, different PI3K subunit isoforms in mast cells. In this review, we discuss how PI3K influences the mast cell processes described above. Furthermore, we describe how different mast cell receptors use alternative isoforms of PI3K for these functions and discuss potential downstream targets of these isoforms.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • 1-Phosphatidylinositol 4-Kinase / immunology
  • 1-Phosphatidylinositol 4-Kinase / metabolism*
  • Animals
  • Calcium / immunology
  • Calcium / metabolism
  • Cell Degranulation / immunology
  • Cytokines / immunology*
  • Cytokines / metabolism
  • Forkhead Transcription Factors / immunology
  • Forkhead Transcription Factors / metabolism
  • Humans
  • Mast Cells / enzymology
  • Mast Cells / immunology*
  • PTEN Phosphohydrolase / immunology
  • PTEN Phosphohydrolase / metabolism
  • Phosphoric Monoester Hydrolases / immunology
  • Phosphoric Monoester Hydrolases / metabolism
  • Protein Isoforms / immunology
  • Protein Isoforms / metabolism
  • Protein Kinases / immunology
  • Protein Kinases / metabolism
  • Protein-Serine-Threonine Kinases / immunology
  • Protein-Serine-Threonine Kinases / metabolism
  • Proto-Oncogene Proteins c-akt / immunology
  • Proto-Oncogene Proteins c-akt / metabolism
  • Proto-Oncogene Proteins c-kit / immunology
  • Proto-Oncogene Proteins c-kit / metabolism
  • Receptors, IgE / immunology
  • Receptors, IgE / metabolism
  • TOR Serine-Threonine Kinases

Substances

  • Cytokines
  • Forkhead Transcription Factors
  • Protein Isoforms
  • Receptors, IgE
  • Protein Kinases
  • MTOR protein, human
  • TOR Serine-Threonine Kinases
  • 1-Phosphatidylinositol 4-Kinase
  • Proto-Oncogene Proteins c-kit
  • Protein-Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt
  • Phosphoric Monoester Hydrolases
  • PTEN Phosphohydrolase
  • Calcium