A convenient approach towards 2'-O-modified RNA-oligonucleotides on solid support using universal nucleosides

Nucleic Acids Symp Ser (Oxf). 2008:(52):331-2. doi: 10.1093/nass/nrn167.

Abstract

Here we report a novel synthetic pathway for an efficient modification of RNA-oligonucleotides on solid-support using universal nucleosides bearing a 2'-O-aminopropyl-tether.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / chemistry
  • Biochemistry / methods
  • Carboxylic Acids / chemistry
  • Nucleosides / chemistry*
  • Oligoribonucleotides / chemical synthesis*
  • Oligoribonucleotides / chemistry
  • Phosphoric Acids / chemistry

Substances

  • Amides
  • Carboxylic Acids
  • Nucleosides
  • Oligoribonucleotides
  • Phosphoric Acids
  • phosphoramidic acid