Laminar analysis of the role of GluR1 in experience-dependent and synaptic depression in barrel cortex

Nat Neurosci. 2008 Oct;11(10):1140-2. doi: 10.1038/nn.2188. Epub 2008 Sep 7.


Several synaptic depression mechanisms have been described for the hippocampus, cerebellum and neocortex in vitro, but little is known about which, if any, are engaged during experience-dependent depression (EDD). We found that EDD in the mouse barrel cortex depends on the AMPA subunit GluR1 in layers II/III and IV, but not in layer V, and that long-term depression is also GluR1 dependent in the IV-II/III, but not II/III-V, pathway.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Long-Term Synaptic Depression / genetics
  • Long-Term Synaptic Depression / physiology*
  • Mice
  • Mice, Knockout
  • Receptors, AMPA / deficiency
  • Receptors, AMPA / physiology*
  • Sensory Deprivation / physiology
  • Somatosensory Cortex / anatomy & histology*
  • Somatosensory Cortex / physiology*
  • Synaptic Transmission / genetics
  • Synaptic Transmission / physiology*
  • Vibrissae / innervation


  • Receptors, AMPA
  • glutamate receptor ionotropic, AMPA 1