Obesity and type 2 diabetes are associated with an increased risk of developing cancer and a worse prognosis; epidemiological and mechanistic evidence

Exp Clin Endocrinol Diabetes. 2008 Sep;116 Suppl 1:S4-6. doi: 10.1055/s-2008-1081488. Epub 2008 Sep 5.

Abstract

Both obesity and Type 2 diabetes are independently associated with an increased risk of developing cancer and an increased mortality. The etiology is yet to be determined but insulin resistance and hyperinsulinemia maybe important factors. Hyperglycemia, hyperlipidemia and inflammatory cytokines in addition to the insulin-like growth factors are also possible factors involved in the process.

Publication types

  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetes Mellitus, Type 2 / epidemiology
  • Diabetes Mellitus, Type 2 / genetics
  • Disease Models, Animal
  • Humans
  • Models, Biological
  • Neoplasms / diagnosis*
  • Neoplasms / epidemiology*
  • Neoplasms / etiology*
  • Neoplasms / genetics
  • Obesity / complications*
  • Obesity / epidemiology
  • Obesity / genetics
  • Prognosis
  • Risk Factors
  • Signal Transduction / genetics*
  • Signal Transduction / physiology