Physical activity and mortality in men and women with coronary heart disease: a prospective population-based cohort study in Norway (the HUNT study)

Eur J Cardiovasc Prev Rehabil. 2008 Dec;15(6):639-45. doi: 10.1097/HJR.0b013e3283101671.


Background: Patients with established coronary heart disease (CHD) are encouraged to be physically active to prevent disease progression and to prolong life. The amount and intensity of exercise required for risk reduction in patients with CHD is not yet fully resolved.

Design: Population-based prospective cohort study with 18 years of follow-up.

Methods: A linkage between a Norwegian population-based study (Nord-Trøndelag health study) and the Cause of Death Registry at Statistics Norway. Exercise amount and intensity were measured at baseline (1984-1986) in 2137 men and 1367 women with CHD.

Results: During 18 years of follow-up, 1741 (81.6%) men and 1100 (80.5%) women died. Compared with the reference category (no activity), one weekly exercise session was associated with a lower all-cause mortality, both in men (relative risk 0.80, 95% confidence interval 0.68-0.94) and women (relative risk 0.68, 95% confidence interval 0.55-0.83). This inverse association became stronger with increasing frequency (P< or =0.001 for men and women). Those who reported moderate or high-intensity exercise had a somewhat lower risk of death than those who exercised with low intensity.

Conclusion: Exercise training reduced all-cause and cardiovascular mortality in men and women with CHD. This study adds significantly to the sparse literature regarding prospective data on physical activity, exercise intensity and mortality in CHD patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cohort Studies
  • Coronary Disease / mortality*
  • Coronary Disease / physiopathology*
  • Disease Progression
  • Exercise*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Norway / epidemiology
  • Proportional Hazards Models
  • Prospective Studies
  • Risk Assessment
  • Risk Reduction Behavior*
  • Time Factors
  • Young Adult