Risk stratification in acute decompensated heart failure: the role of cardiac troponin

Nat Clin Pract Cardiovasc Med. 2008 Nov;5(11):680-1. doi: 10.1038/ncpcardio1342. Epub 2008 Sep 9.


Cardiac troponins provide important prognostic information in patients with acute decompensated heart failure. In a large study by the ADHERE Investigators, 6.2% of 67,924 patients with acute decompensated heart failure were positive for cardiac troponin; these individuals had lower blood pressure and lower ejection fraction than those who were negative for troponin. The study revealed that in-hospital mortality was significantly higher for troponin-positive patients than for troponin-negative individuals (8.0% vs 2.7%; P<0.001). Future studies need to define which treatment changes could improve outcome in troponin-positive patients with acute decompensated heart failure.

MeSH terms

  • Acute Disease
  • Biomarkers / blood
  • Blood Pressure
  • Heart Failure / blood*
  • Heart Failure / mortality*
  • Heart Failure / physiopathology
  • Heart Failure / therapy
  • Hospital Mortality
  • Humans
  • Odds Ratio
  • Risk Assessment
  • Stroke Volume
  • Treatment Outcome
  • Troponin / blood*


  • Biomarkers
  • Troponin