Primary multifocal osseous lymphoma in a child

Pediatr Radiol. 2008 Dec;38(12):1338-41. doi: 10.1007/s00247-008-0964-0. Epub 2008 Sep 9.


We report a case of primary multifocal osseous lymphoma in a 6-year-old girl presenting with multifocal osteolytic lesions without systemic symptoms or identifiable non-osseous primary tumor. The differential diagnoses for such a presentation include histiocytosis X, chronic recurrent multifocal osteomyelitis, acute lymphoblastic leukemia, metastatic disease, and primary bone lymphoma. Although non-Hodgkin lymphoma is common in the pediatric population, its presentation as a primary bone tumor, especially with multifocal disease, is extremely rare and is frequently misdiagnosed. We hope that awareness of this entity will help radiologists achieve timely diagnosis and intervention.

Publication types

  • Case Reports

MeSH terms

  • Arthralgia / etiology
  • Biopsy / methods
  • Bone Neoplasms / complications
  • Bone Neoplasms / diagnosis*
  • Child
  • Diagnosis, Differential
  • Female
  • Femur / diagnostic imaging
  • Femur / pathology
  • Fluorodeoxyglucose F18
  • Humans
  • Lymphoma, Non-Hodgkin / complications
  • Lymphoma, Non-Hodgkin / diagnosis*
  • Magnetic Resonance Imaging
  • Positron-Emission Tomography / methods
  • Radiopharmaceuticals
  • Rare Diseases
  • Tomography, X-Ray Computed
  • Whole Body Imaging / methods


  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18