Levodopa-related motor complications--phenomenology

Mov Disord. 2008:23 Suppl 3:S509-14. doi: 10.1002/mds.22021.

Abstract

Long term levodopa therapy in Parkinson's disease (PD) results in a range of problems. These include fluctuations in FD symptoms termed motor fluctuations, as well as non-motor symptoms, termed non-motor fluctuations. Here we review the phenomenology and methods of assessing these levodopa-related complications.

Publication types

  • Review

MeSH terms

  • Antiparkinson Agents / adverse effects
  • Cognition Disorders / chemically induced
  • Disease Progression
  • Drug Administration Schedule
  • Dyskinesias / etiology
  • Fatigue
  • Humans
  • Levodopa / adverse effects*
  • Levodopa / pharmacokinetics
  • Levodopa / therapeutic use
  • Mood Disorders / chemically induced
  • Motor Activity / drug effects*
  • Parkinson Disease / drug therapy
  • Parkinson Disease / physiopathology
  • Parkinson Disease / psychology
  • Treatment Failure

Substances

  • Antiparkinson Agents
  • Levodopa