Re-identification of clinical isolates of the Pseudallescheria boydii-complex involved in near-drowning

Mycoses. 2008 Sep:51 Suppl 3:11-6. doi: 10.1111/j.1439-0507.2008.01579.x.

Abstract

Fungal infections caused by the members of the genera Pseudallescheria and/or Scedosporium are important complications in patients after near-drowning. As the taxonomy of Pseudallescheria and Scedosporium has been revised, clinical isolates from 11 patients, after near-drowning, previously identified as P. boydii or S. apiospermum had to be re-identified. S. apiospermum, now separated from P. boydii as a distinct species, was found most frequently (n = 8), while S. aurantiacum, recently described as new species and P. boydii were less common (n = 2 and n = 1, respectively). Three patients near-drowned during the Tsunami 2004 were infected by different species of the P. boydii complex. In vitro testing resulted in lowest minimal inhibitory concentration (MICs) for voriconazole (range 0.25-2.0 microg ml(-1)).

MeSH terms

  • Adult
  • Aged
  • Antifungal Agents / pharmacology
  • Brain / microbiology
  • Child, Preschool
  • DNA, Fungal / analysis
  • DNA, Ribosomal Spacer / analysis
  • Female
  • Humans
  • Infant
  • Lung / microbiology
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Mycetoma / microbiology*
  • Mycological Typing Techniques
  • Near Drowning / complications*
  • Pseudallescheria / classification*
  • Pseudallescheria / drug effects
  • Pseudallescheria / genetics
  • Pseudallescheria / isolation & purification
  • Scedosporium / classification*
  • Scedosporium / drug effects
  • Scedosporium / genetics
  • Scedosporium / isolation & purification
  • Skin / microbiology
  • Species Specificity

Substances

  • Antifungal Agents
  • DNA, Fungal
  • DNA, Ribosomal Spacer