Effect of calorie-protein supplementation on the cognitive recovery of patients with subacute stroke

Nutr Neurosci. 2008 Oct;11(5):235-40. doi: 10.1179/147683008X301586.


Introduction: The objective of this study was to investigate whether protein-calorie supplementation may enhance the cognitive retrieval of patients with stroke.

Patients and methods: A randomized, double-blind, controlled pilot clinical trial was performed comparing diet and diet plus protein-calorie supplementation regimens. The subjects were 48 patients with subacute stroke (>or14 days from index event). Anthropometric and nutritional (3-day diary) variables, cognitive function (Mini-Mental State Examination; MMSE) were determined before and 21 days after randomization in control and daily supplemented group (formula providing 250 kcal + 20 g protein).

Results: At day 21 after starting the protocol, only the supplemented group significantly improved their performance to MMSE (log(10)MMSE +0.6+/-0.4 score; P=0.01 from baseline).

Conclusions: Protein-calorie supplementation may enhance the recovery of cognitive function in subacute stroke patients.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Cognition*
  • Dietary Proteins / administration & dosage*
  • Double-Blind Method
  • Energy Intake*
  • Female
  • Food, Formulated
  • Humans
  • Male
  • Middle Aged
  • Pilot Projects
  • Stroke / diet therapy*


  • Dietary Proteins