PGC-1 Coactivators and Skeletal Muscle Adaptations in Health and Disease

Curr Opin Genet Dev. 2008 Oct;18(5):426-34. doi: 10.1016/j.gde.2008.07.018. Epub 2008 Sep 7.

Abstract

Skeletal muscle adapts to physiological demands by altering a number of programs of gene expression, including those driving mitochondrial biogenesis, angiogenesis, and fiber composition. Recently, the PGC-1 transcriptional coactivators have emerged as key players in the regulation of these adaptations. Many signaling cascades important in muscle physiology impinge directly on PGC-1 expression or activity. In turn, the PGC-1s powerfully activate many of the programs of muscle adaptation. These findings have implications for our understanding of muscle responses to physiological conditions like exercise, as well as in pathological conditions such as cachexia, dystrophy, and peripheral vascular disease.

Publication types

  • Review

MeSH terms

  • Adaptation, Physiological
  • Animals
  • Gene Expression Regulation
  • Mice
  • Muscle Fibers, Skeletal / metabolism
  • Muscle Fibers, Skeletal / physiology
  • Muscle, Skeletal / metabolism*
  • Muscle, Skeletal / physiology
  • Muscular Diseases / genetics
  • Muscular Diseases / metabolism*
  • Neovascularization, Physiologic / genetics
  • Oxidation-Reduction
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
  • Trans-Activators / metabolism
  • Trans-Activators / physiology
  • Transcription Factors / genetics
  • Transcription Factors / physiology*

Substances

  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
  • Ppargc1a protein, mouse
  • Trans-Activators
  • Transcription Factors
  • peroxisome-proliferator-activated receptor-gamma coactivator-1