History of unemployment predicts future elevations in C-reactive protein among male participants in the Coronary Artery Risk Development in Young Adults (CARDIA) Study

Ann Behav Med. 2008 Oct;36(2):176-85. doi: 10.1007/s12160-008-9056-5. Epub 2008 Sep 11.

Abstract

Background: Unemployment is associated with risk of future morbidity and premature mortality.

Purpose: To examine whether unemployment history predicts future C-reactive protein (CRP) levels in male participants in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.

Methods: Unemployment, body mass index (BMI), and health behaviors were measured at 7, 10, and 15 years post-recruitment. CRP was measured at Years 7 and 15.

Results: Having a history of unemployment at Year 10 was associated with higher CRP at Year 15, independent of age, race, BMI, Year 7 CRP, Year 15 unemployment, and average income across Years 10-15. Poor health practices and depressive symptoms explained 22% of the association, but Year 10 unemployment history remained a significant predictor. Findings did not differ across age, race, education, or income.

Conclusions: Discrete episodes of unemployment may have long-term implications for future CRP levels.

Publication types

  • Multicenter Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • African Americans
  • C-Reactive Protein / analysis*
  • Cohort Studies
  • Coronary Artery Disease / blood
  • Coronary Artery Disease / etiology
  • Coronary Artery Disease / psychology*
  • Health Behavior
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Population Surveillance*
  • Risk Factors
  • Socioeconomic Factors
  • Statistics, Nonparametric
  • Stress, Psychological / blood*
  • Stress, Psychological / complications
  • Unemployment / psychology*
  • Whites

Substances

  • C-Reactive Protein