Lymphocyte subset reconstitution patterns in children with small bowel transplantation induced with steroid-free rabbit anti-human thymocyte globulin

Pediatr Transplant. 2009 May;13(3):353-9. doi: 10.1111/j.1399-3046.2008.01010.x. Epub 2008 Sep 10.

Abstract

Multiple measurements (n = 212) of lymphocyte subsets in 67 children treated with steroid-free Tacrolimus, and rabbit anti-human thymocyte globulin induction demonstrate early reconstitution of T-cytotoxic and NK cells. Reconstitution of CD4+ cells is complete after the second post-transplant year. During the period at risk for rejection, NK and T-cytotoxic cell counts are significantly higher among Rejectors. During periods at increased risk for EBV viral infection, CD4 counts bear a significant inverse relationship to EBV viral load in a subset of at-risk recipients. Rejection-prone children also demonstrate significantly higher counts of total lymphocytes, Tc and NK cells prior to SBTx, and may illustrate one basis for enhanced baseline immunocompetence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Antilymphocyte Serum / immunology
  • Antilymphocyte Serum / therapeutic use*
  • CD4-Positive T-Lymphocytes / immunology
  • Child
  • Child, Preschool
  • Female
  • Graft Survival / immunology
  • Herpesvirus 4, Human
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Infant
  • Intestine, Small / transplantation*
  • Killer Cells, Natural / immunology
  • Lymphocyte Subsets / immunology*
  • Male
  • Organ Transplantation* / mortality
  • T-Lymphocytes / immunology*
  • T-Lymphocytes, Cytotoxic / immunology
  • Tacrolimus / therapeutic use
  • Viral Load
  • Young Adult

Substances

  • Antilymphocyte Serum
  • Immunosuppressive Agents
  • Tacrolimus