Germline MC1R variants and BRAF mutant melanoma

J Invest Dermatol. 2008 Oct;128(10):2354-6. doi: 10.1038/jid.2008.236.


Recent studies have demonstrated that melanocortin-1 receptor (MC1R) variants increase the risk of melanomas harboring BRAF mutations. This finding provides insight into the relationship between host genotype and selection for somatic mutation type. Additional larger studies are required in diverse populations to further examine the interaction between MC1R and BRAF in different melanoma subtypes.

Publication types

  • Comment
  • Editorial

MeSH terms

  • Genetic Predisposition to Disease
  • Genetic Variation*
  • Germ-Line Mutation*
  • Humans
  • Melanoma / genetics*
  • Mutation*
  • Proto-Oncogene Proteins B-raf / genetics*
  • Receptor, Melanocortin, Type 1 / genetics*
  • Skin Neoplasms / genetics*


  • Receptor, Melanocortin, Type 1
  • BRAF protein, human
  • Proto-Oncogene Proteins B-raf