The Alliance of sphingosine-1-phosphate and Its Receptors in Immunity

Nat Rev Immunol. 2008 Oct;8(10):753-63. doi: 10.1038/nri2400.

Abstract

Sphingosine-1-phosphate (S1P) is a biologically active metabolite of plasma-membrane sphingolipids that is essential for immune-cell trafficking. Its concentration is increased in many inflammatory conditions, such as asthma and autoimmunity. Much of the immune function of S1P results from the engagement of a family of G-protein-coupled receptors (S1PR1-S1PR5). Recent findings on the role of S1P in immunosurveillance, the discovery of regulatory mechanisms in S1P-mediated immune-cell trafficking and new advances in understanding the mechanism by which S1P affects immune-cell function indicate that the alliance between S1P and its receptors has a fundamental role in immunity.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Animals
  • Cell Movement
  • Chemotaxis
  • Dendritic Cells / immunology*
  • Dendritic Cells / metabolism
  • Humans
  • Lymphocytes / immunology*
  • Lymphocytes / metabolism
  • Lysophospholipids / immunology
  • Lysophospholipids / metabolism*
  • Macrophages / immunology*
  • Macrophages / metabolism
  • Mast Cells / immunology*
  • Mast Cells / metabolism
  • Receptors, Lysosphingolipid / immunology
  • Receptors, Lysosphingolipid / metabolism*
  • Signal Transduction
  • Sphingosine / analogs & derivatives*
  • Sphingosine / immunology
  • Sphingosine / metabolism

Substances

  • Lysophospholipids
  • Receptors, Lysosphingolipid
  • sphingosine 1-phosphate
  • Sphingosine