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Meta-Analysis
, 33 (5), 405-12

Provocation of Obsessive-Compulsive Symptoms: A Quantitative Voxel-Based Meta-Analysis of Functional Neuroimaging Studies

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Meta-Analysis

Provocation of Obsessive-Compulsive Symptoms: A Quantitative Voxel-Based Meta-Analysis of Functional Neuroimaging Studies

Jean-Yves Rotge et al. J Psychiatry Neurosci.

Abstract

Objective: Recent functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) studies based on the symptom provocation paradigm have explored neural correlates of the cognitive and emotional processes associated with the emergence of obsessive-compulsive disorder (OCD) symptoms. Although most studies showed the involvement of cortico-subcortical loops originating in the orbitofrontal cortex and the anterior cingulate cortex, an increased activity within numerous other regions of the brain has inconsistently been reported across studies. To provide a quantitative estimation of the cerebral activation patterns related to the performance of the symptom provocation task by OCD patients, we conducted a voxel-based meta-analysis.

Methods: We searched the PubMed and MEDLINE databases for studies that used fMRI and PET and that were based on the symptom provocation paradigm. We entered data into a paradigm-driven activation likelihood estimation meta-analysis.

Results: We found significant likelihoods of activation in cortical and subcortical regions of the orbitofrontal and anterior cingulate loops. The left dorsal frontoparietal network, including the dorsolateral prefrontal cortex and precuneus, and the left superior temporal gyrus also demonstrated significant likelihoods of activation.

Conclusion: Consistent results across functional neuroimaging studies suggest that the orbitofrontal and anterior cingulate cortices are involved in the mediation of obsessive-compulsive symptoms. Based on recent literature, we suggest that activations within the dorsal frontoparietal network might be related to patients' efforts to resist the obsessive processes induced by the provocation task. Further research should elucidate the specific neural correlates of the various cognitive and emotional functions altered in OCD.

Keywords: magnetic resonance imaging; obsessive-compulsive disorder; positron-emission tomography.

Figures

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Fig. 1: Meta-analytic activation map based on symptom provocation studies involving patients with obsessive–compulsive disorder. Regions of the brain showing a significant activation likelihood are highlighted in red on axial slices of an individual brain in the Talairach space. They include the bilateral middle and inferior frontal gyri (z = –16, –12, –8), bilateral cingulate cortex (z = 0, 4, 44), bilateral globus pallidus (z = –4, 0, 4), left hippocampus (z = –24) and right uncus (z = –20). We obtained a unilateral significant threshold in the superior temporal gyrus (z = –20, –16) and precuneus (z = 52) for the left hemisphere, and in the medial frontal gyrus (z = 40) and thalamus (z = 4) for the right hemisphere.

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