Volumizing effect of a new hyaluronic acid sub-dermal facial filler: a retrospective analysis based on 102 cases

J Cosmet Laser Ther. 2008 Sep;10(3):134-42. doi: 10.1080/14764170802154607.


Introduction: Many signs of aging are due to the loss of subcutaneous fat. Dermal fillers are non-surgical cosmetic treatments used to restore facial volume. Voluma is a new hyaluronic acid sub-dermal facial filler. The objective of this study was to assess its effectiveness in maintaining increased volume for up to 18 months post-treatment and its safety.

Methods: Retrospective record analysis was made for 102 patients (93 females, nine males; mean age: 51.27 years) who received Voluma injected into the midface. All patients were assessed at baseline and at 1 month and 6-18 months post-injection.

Results: Investigator Global Aesthetic Improvement assessment after 1 month and 6-18 months showed that most patients were 'much' or 'very much' improved. Investigator volume loss assessment confirmed that most patients were either stage 1 or 2 (normal or slight ptosis) 1 month post-treatment, which was maintained at 6-18 months. Patient efficacy assessment was 'very good' or 'good' in most cases.

Conclusions: Voluma provides aesthetic improvements according to investigator and patient assessment for up to 18 months post-treatment. Combination treatment comprising facial fillers and botulinum neurotoxin can enhance treatment benefits. Further methodologically rigorous studies are required to establish the performance of Voluma alone and in combination.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging / physiology
  • Cosmetic Techniques*
  • Dermis*
  • Face*
  • Female
  • Humans
  • Hyaluronic Acid / therapeutic use*
  • Injections
  • Male
  • Middle Aged
  • Retrospective Studies


  • Hyaluronic Acid