Molecular biology of botulinum neurotoxin serotype A: a cosmetic perspective

J Cosmet Dermatol. 2008 Sep;7(3):221-5. doi: 10.1111/j.1473-2165.2008.00392.x.


Cosmetic use of botulinum neurotoxin serotype A (BoNT/A) involves low doses of toxin administered for facial wrinkles and hyperhidrosis. The structural and functional properties of BoNT/A can affect the degree and duration of effect. Actively using the injected muscle is favorable as it exposes more receptors to BoNT/A. Divided doses of BoNT/A at an interval of more than 3 days may be longer lasting than single dose by blocking nascent neuronal sprouts. Antibodies are unlikely to be effective in BoNT/A neutralization because of the large area of receptor interaction. Several commonly used drugs including zinc and chloroquine can interact with BoNT/A, necessitating dosage adjustment for optimum effect. Serotype E (BoNT/E) can emerge as an antidote for BoNT/A for cosmetic use.

MeSH terms

  • Beauty Culture / trends*
  • Botulinum Toxins, Type A / administration & dosage*
  • Botulinum Toxins, Type A / genetics*
  • Face*
  • Humans
  • Hyperhidrosis / drug therapy
  • Neuromuscular Agents / administration & dosage*
  • Skin Aging / drug effects*
  • Treatment Outcome


  • Neuromuscular Agents
  • Botulinum Toxins, Type A