Novel biomarkers for predicting preeclampsia

Trends Cardiovasc Med. 2008 Jul;18(5):186-94. doi: 10.1016/j.tcm.2008.07.002.

Abstract

Preeclampsia is a major cause of maternal morbidity and mortality worldwide. Despite decades of research into the condition, the ability of clinicians to predict preeclampsia prior to the onset of symptoms has not improved significantly. In this review, we will examine the pathophysiology underlying preeclampsia and will look at potential biomarkers for early prediction and diagnosis. In addition, we will explore potential future areas of research into the condition.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Activins / metabolism
  • Angiogenesis Inducing Agents / metabolism
  • Antigens, CD / metabolism
  • Apolipoproteins E / metabolism
  • Biomarkers / metabolism*
  • Endoglin
  • Female
  • Humans
  • Inhibins / metabolism
  • Insulin Resistance
  • Pre-Eclampsia / diagnosis*
  • Pre-Eclampsia / physiopathology
  • Pregnancy
  • Pregnancy-Associated Plasma Protein-A / metabolism
  • Receptors, Cell Surface / metabolism
  • Vascular Endothelial Growth Factor Receptor-1 / metabolism

Substances

  • Angiogenesis Inducing Agents
  • Antigens, CD
  • Apolipoproteins E
  • Biomarkers
  • ENG protein, human
  • Endoglin
  • Receptors, Cell Surface
  • activin A
  • inhibin A
  • Activins
  • Inhibins
  • FLT1 protein, human
  • Vascular Endothelial Growth Factor Receptor-1
  • PAPPA2 protein, human
  • Pregnancy-Associated Plasma Protein-A