Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2008 Sep;21(3):521-41.
doi: 10.1016/j.beha.2008.07.010.

Dendritic Cell Vaccines in Acute Leukaemia

Affiliations
Review

Dendritic Cell Vaccines in Acute Leukaemia

Caroline Duncan et al. Best Pract Res Clin Haematol. .

Abstract

There is a need for novel treatment for acute leukaemia as relapse rates remain unacceptably high. Immunotherapy aims to stimulate the patient's immune responses to recognize and destroy leukaemia cells whilst activating immune memory. The qualities of the most potent professional antigen-presenting cell, the dendritic cell (DC), can be used to stimulate leukaemia-specific cytotoxic T cells. DCs can be loaded with leukaemia antigens, or leukaemia blasts can be modified to express DC-like properties for use in vaccine therapy. This chapter will review the rationale for DC vaccine therapy, the preclinical and clinical trials to date, the barriers to successful DC vaccine therapies and the role of immune adjuncts to improve outcomes.

Similar articles

See all similar articles

Cited by 3 articles

Substances

LinkOut - more resources

Feedback