Sulfotanshinone Sodium Injection could decrease fibrinogen level and improve clinical outcomes in patients with unstable angina pectoris

Int J Cardiol. 2009 Jun 26;135(2):254-5. doi: 10.1016/j.ijcard.2008.03.020. Epub 2008 Sep 14.

Abstract

We randomly divided 100 unstable angina pectoris (UAP) patients into two groups: the trial group received Sulfotanshinone Sodium Injection (SSI) 60 mg combined with a loading dose of 300 mg aspirin and a maintenance dose of 100 mg of aspirin plus baseline therapy, and the control group received the same doses of aspirin and baseline therapy. 94 patients completed treatment. After 4 weeks' medication, the severity of angina pectoris improved in both groups, with a significant improvement in total effective rate in the trial group but no difference in the total effective rate of improvement seen on ECG. Compared with baseline level, FIB level after treatment decreased significantly in both groups but to a greater extent in the trial group. Similar changes in DD levels were observed in both groups. With a background of aspirin and baseline therapy, SSI can significantly attenuate angina pectoris attacks in patients with UAP which may be associated with the decreased level of FIB.

Publication types

  • Letter
  • Randomized Controlled Trial

MeSH terms

  • Abietanes
  • Angina, Unstable / blood
  • Angina, Unstable / drug therapy*
  • Anticoagulants / administration & dosage*
  • Aspirin / administration & dosage
  • Dimerization
  • Drugs, Chinese Herbal / administration & dosage*
  • Female
  • Fibrinogen / chemistry
  • Fibrinogen / metabolism*
  • Fibrinolytic Agents / administration & dosage
  • Humans
  • Male
  • Middle Aged
  • Phenanthrenes / administration & dosage*
  • Salvia miltiorrhiza*

Substances

  • Abietanes
  • Anticoagulants
  • Drugs, Chinese Herbal
  • Fibrinolytic Agents
  • Phenanthrenes
  • tanshinone
  • Fibrinogen
  • Aspirin