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. 2009 Jan;37(Database issue):D820-3.
doi: 10.1093/nar/gkn593. Epub 2008 Sep 12.

Database for Exploration of Functional Context of Genes Implicated in Ovarian Cancer

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Free PMC article

Database for Exploration of Functional Context of Genes Implicated in Ovarian Cancer

Mandeep Kaur et al. Nucleic Acids Res. .
Free PMC article

Abstract

Ovarian cancer (OC) is becoming the most common gynecological cancer in developed countries and the most lethal gynecological malignancy. It is also the fifth leading cause of all cancer-related deaths in women. The identification of diagnostic biomarkers and development of early detection techniques for OC largely depends on the understanding of the complex functionality and regulation of genes involved in this disease. Unfortunately, information about these OC genes is scattered throughout the literature and various databases making extraction of relevant functional information a complex task. To reduce this problem, we have developed a database dedicated to OC genes to support exploration of functional characterization and analysis of biological processes related to OC. The database contains general information about OC genes, enriched with the results of transcription regulation sequence analysis and with relevant text mining to provide insights into associations of the OC genes with other genes, metabolites, pathways and nuclear proteins. Overall, it enables exploration of relevant information for OC genes from multiple angles, making it a unique resource for OC and will serve as a useful complement to the existing public resources for those interested in OC genetics. Access is free for academic and non-profit users and database can be accessed at http://apps.sanbi.ac.za/ddoc/.

Figures

Figure 1.
Figure 1.
A color-coded network generated from text-mining results for ABCB1 gene. Networks represents that MRP1 (a nuclear protein) appeared 95 times in the abstracts (as both have been shown to transport same substrates) with ABCB1 (P-gp), which in turn has been reviewed 470 times with medium-chain dehydrogenase/reductase (MDR) enzyme. This represents a small network of different biological entities, which have been reviewed with ABCB1 gene in the literature. This gives the user a view and understanding of varied biological interactions a gene might have in the studies published so far.

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