Studies on the nature of anti-platelet aggregatory factors in the seeds of the Amazonian Herb Guarana (Paullinia cupana)

Int J Vitam Nutr Res. 2008 Mar;78(2):96-101. doi: 10.1024/0300-9831.78.2.96.


Guarana (Paullinia cupana) is a popular herb native to the Amazon Basin and used extensively in soft drinks in Brazil, other Latin American countries, and more recently in the United States. Extracts derived from the dried seeds of guarana possess strong anti-platelet aggregatory properties. In this study, an active fraction containing this activity was purified and analyzed by high-performance liquid chromatography/mass spectrometry (HPLC/MS) techniques. It was noted that this fraction contains catechins, epicatechins, and their dimers, with a small amount of caffeine. It is suggested that complexes containing caffeine and catechins (and their dimers) might be responsible for anti-platelet aggregatory activity in guarana seeds and might offer health benefits towards decreasing risk of thrombosis and cardiovascular disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromatography, High Pressure Liquid
  • Humans
  • Paullinia / chemistry*
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Platelet Aggregation / drug effects
  • Platelet Aggregation Inhibitors / chemistry*
  • Platelet Aggregation Inhibitors / isolation & purification
  • Platelet Aggregation Inhibitors / pharmacology*
  • Platelet-Rich Plasma / metabolism*
  • Seeds / chemistry
  • Spectrometry, Mass, Electrospray Ionization
  • Thromboxanes / biosynthesis


  • Plant Extracts
  • Platelet Aggregation Inhibitors
  • Thromboxanes