Oscillatory bands, neuronal synchrony and hippocampal function: implications of the effects of prenatal choline supplementation for sleep-dependent memory consolidation

Brain Res. 2008 Oct 27;1237:176-94. doi: 10.1016/j.brainres.2008.08.077. Epub 2008 Sep 9.

Abstract

Choline supplementation of the maternal diet has long-term facilitative effects on spatial and temporal memory processes in the offspring. To further delineate the impact of early nutritional status on brain and behavior, we examined effects of prenatal-choline availability on hippocampal oscillatory frequency bands in 12 month-old male and female rats. Adult offspring of time-pregnant dams that were given a deficient level of choline (DEF=0.0 g/kg), sufficient choline (CON=1.1 g/kg) or supplemental choline (SUP=3.5 g/kg) in their chow during embryonic days (ED) 12-17 were implanted with an electroencephalograph (EEG) electrode in the hippocampal dentate gyrus in combination with an electromyograph (EMG) electrode patch implanted in the nuchal muscle. Five consecutive 8-h recording sessions revealed differential patterns of EEG activity as a function of awake, slow-wave sleep (SWS) and rapid-eye movement (REM) sleep states and prenatal choline status. The main finding was that SUP rats displayed increased power levels of gamma (30-100 Hz) band oscillations during all phases of the sleep/wake cycle. These findings are discussed within the context of a general review of neuronal oscillations (e.g., delta, theta, and gamma bands) and synchronization across multiple brain regions in relation to sleep-dependent memory consolidation in the hippocampus.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Algorithms
  • Animals
  • Biological Clocks / drug effects
  • Biological Clocks / physiology
  • Choline / administration & dosage*
  • Dietary Supplements
  • Electroencephalography* / methods
  • Electromyography
  • Female
  • Hippocampus / physiology*
  • Male
  • Memory / drug effects*
  • Memory / physiology
  • Nootropic Agents / administration & dosage*
  • Pregnancy
  • Prenatal Nutritional Physiological Phenomena*
  • Rats
  • Sleep / drug effects*
  • Sleep / physiology
  • Time Factors

Substances

  • Nootropic Agents
  • Choline