Flucloxacillin-induced liver injury

Toxicology. 2008 Dec 30;254(3):158-63. doi: 10.1016/j.tox.2008.08.009. Epub 2008 Aug 29.


Flucloxacillin is a common cause of drug-induced liver injury in Europe, affecting in the region of 8.5 in every 100,000 first time users of the drug. The mechanism by which the drug causes the liver injury is currently unknown but it is believed to be influenced by a combination of genetic and environmental factors. This review summarises what is currently known about the disposition of flucloxacillin in the liver, considers potential mechanisms by which flucloxacillin may cause the liver injury, and suggests candidate genes which could determine individual susceptibility to flucloxacillin-induced liver injury.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-Bacterial Agents / adverse effects*
  • Bile Acids and Salts / metabolism
  • Chemical and Drug Induced Liver Injury*
  • Cholestasis / chemically induced
  • Cholestasis / genetics
  • Europe / epidemiology
  • Floxacillin / adverse effects*
  • Genetic Predisposition to Disease
  • Homeostasis / drug effects
  • Humans
  • Liver Diseases / epidemiology
  • Liver Diseases / physiopathology


  • Anti-Bacterial Agents
  • Bile Acids and Salts
  • Floxacillin