Chronic mianserin treatment decreases 5-HT2 receptor binding without altering 5-HT2 receptor mRNA levels

Eur J Pharmacol. 1991 Jun 19;207(2):169-72. doi: 10.1016/0922-4106(91)90093-w.


Rats were injected with 15 mg/kg (i.p.) mianserin or vehicle (saline) for 4, 10 or 21 days and 5-HT2 receptor binding and mRNA levels measured. Treatment with mianserin induced a substantial decrease in 5-HT2 radioligand binding (44-59% decrease; P less than 0.05 vs. control). No changes in the amount of 5-HT2 or, as a control, beta-actin mRNAs were found (P greater than 0.05 vs. control). These results indicate that mianserin decreases 5-HT2 radioligand binding without altering steady-state 5-HT2 mRNA levels.

MeSH terms

  • Animals
  • Blotting, Northern
  • DNA Probes
  • Male
  • Mianserin / pharmacology*
  • RNA, Messenger / analysis*
  • Rats
  • Rats, Inbred Strains
  • Receptors, Serotonin / drug effects*
  • Receptors, Serotonin / genetics


  • DNA Probes
  • RNA, Messenger
  • Receptors, Serotonin
  • Mianserin