Genetic diversity among toxigenic and nontoxigenic Vibrio cholerae O1 isolated from the Western Hemisphere

Epidemiol Infect. 1991 Aug;107(1):225-33. doi: 10.1017/s0950268800048846.

Abstract

Multilocus enzyme electrophoresis was used to examine genetic relationships among and between toxigenic and non-toxigenic isolates of Vibrio cholerae O1 obtained from patients and the environment in the US Gulf Coast and surrounding areas. A total of 23 toxigenic and 23 non-toxigenic strains were examined. All the toxigenic and 7 of the non-toxigenic strains had the same alleles at 16 enzyme loci, whereas the balance of the nontoxigenic strains had 9 distinct combinations of alleles. This study suggests that all of the toxigenic strains belong to a single clone, and that while some of the non-toxigenic isolates were related, most were of diverse origin.

MeSH terms

  • Alleles
  • Brazil
  • Cholera / microbiology*
  • Cholera Toxin / biosynthesis
  • Cluster Analysis
  • Electrophoresis, Starch Gel
  • Environmental Microbiology*
  • Enzymes / analysis
  • Enzymes / genetics
  • Genetic Variation*
  • Genotype
  • Humans
  • Mexico
  • Peru
  • United States
  • Vibrio cholerae / genetics*
  • Vibrio cholerae / isolation & purification
  • Vibrio cholerae / metabolism

Substances

  • Enzymes
  • Cholera Toxin