Nephrotoxic effects of diethylene glycol (DEG) in rats

Exp Pathol. 1991;42(1):27-32. doi: 10.1016/s0232-1513(11)80032-0.


Diethylene glycol (DEG) is a widely used substance with various risks of intoxication. In adult rats influences of DEG on functional parameters are characterized, indicating early signs of nephrotoxicity. A dose dependent proteinuria, an oliguric effect, an increased excretion of free hydrogen ions and a compensated impairment of renal tubular transport processes can be stated (0.25, 0.5 and 0.75 ml DEG/100 g b.m. i.p.). Following a single dose of 0.5 ml DEG/100 g b.m. i.p. the maximally expressed nephrotoxic effect is measurable 4 to 8 days after administration.

MeSH terms

  • Animals
  • Dose-Response Relationship, Drug
  • Ethylene Glycols / toxicity*
  • Female
  • Hydrogen / urine
  • Kidney / drug effects*
  • Kidney / physiology
  • Proteinuria / chemically induced
  • Rats
  • Rats, Inbred Strains


  • Ethylene Glycols
  • diethylene glycol
  • Hydrogen