Daily amylin replacement reverses hepatic glycogen depletion in insulin-treated streptozotocin diabetic rats

FEBS Lett. 1991 Aug 5;287(1-2):203-5. doi: 10.1016/0014-5793(91)80051-4.

Abstract

In streptozotocin-diabetic rats treated with insulin replacement, liver glycogen is some 35% depleted. Five consecutive daily subcutaneous injections with amylin dose-dependently restored liver glycogen to normal levels. Significant increases over insulin-only therapy occurred with amylin doses of 10, 30 and 100 micrograms/day, representing amylin: insulin ratios of 0.22, 0.75 and 2.79.

MeSH terms

  • Amyloid / pharmacology
  • Amyloid / therapeutic use*
  • Animals
  • Diabetes Mellitus, Experimental / drug therapy*
  • Diabetes Mellitus, Experimental / metabolism
  • Glycogen / metabolism*
  • Insulin / therapeutic use*
  • Islet Amyloid Polypeptide
  • Liver / drug effects
  • Liver / metabolism*
  • Male
  • Rats
  • Rats, Inbred Strains

Substances

  • Amyloid
  • Insulin
  • Islet Amyloid Polypeptide
  • Glycogen