Abstract
This article presents the results of a controlled clinical trial evaluating a new at-home treatment to improve gingival health. Designed for overnight application at the gingival margins and in the interproximal spaces, the product is a mucoadhesive gel containing 0.10% cetylpyridinium chloride (CPC) and 0.592% zinc gluconate (ZG). The authors assessed the efficacy and safety of the CPC/ZG gel in adults with low-to-moderate gingival and plaque index scores by comparing clinical and laboratory findings for subjects using the CPC/ZG gel with those for subjects using the control gel (0% CPC and 0.592% ZG). Clinical findings at 3 and 6 months showed statistically significant improvements in two of the three major indices of gingival health in the CPC/ZG group compared with the control group. The performance of the treatment gel was supported by results of microbial analyses of plaque samples.
Publication types
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Comparative Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Anti-Infective Agents, Local / administration & dosage
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Anti-Infective Agents, Local / therapeutic use*
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Cetylpyridinium / administration & dosage
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Cetylpyridinium / therapeutic use*
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Dental Plaque / microbiology
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Dental Plaque / prevention & control*
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Dental Plaque Index
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Female
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Follow-Up Studies
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Gels
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Gingival Hemorrhage / prevention & control
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Gingivitis / prevention & control*
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Gluconates / administration & dosage
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Gluconates / therapeutic use*
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Haemophilus / drug effects
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Humans
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Lithium Compounds / administration & dosage
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Lithium Compounds / therapeutic use
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Male
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Middle Aged
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Periodontal Index
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Prevotella intermedia / drug effects
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Safety
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Streptococcus mutans / drug effects
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Treatment Outcome
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Zinc / administration & dosage
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Zinc / therapeutic use*
Substances
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Anti-Infective Agents, Local
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Gels
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Gluconates
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Lithium Compounds
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Cetylpyridinium
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Zinc
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gluconic acid