Mixed Candida albicans strain populations in colonized and infected mucosal tissues

FEMS Yeast Res. 2008 Dec;8(8):1334-8. doi: 10.1111/j.1567-1364.2008.00438.x. Epub 2008 Sep 15.

Abstract

Multilocus sequence typing of six Candida albicans colonies from primary isolation plates revealed instances of colony-to-colony microvariation and carriage of two strain types in single oropharyngeal and vaginal samples. Higher rates of colony variation in commensal samples suggest selection of types from mixed populations either in the shift to pathogenicity or the response to antifungal treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Candida albicans / classification*
  • Candida albicans / genetics
  • Candida albicans / isolation & purification*
  • Candidiasis, Oral / epidemiology*
  • Candidiasis, Oral / microbiology
  • Candidiasis, Vulvovaginal / epidemiology*
  • Candidiasis, Vulvovaginal / microbiology
  • Carrier State / microbiology
  • DNA, Fungal / analysis
  • DNA, Fungal / genetics
  • Female
  • Humans
  • Mucous Membrane / microbiology*
  • Mycological Typing Techniques
  • Oropharynx / microbiology
  • Sequence Analysis, DNA
  • Vagina / microbiology
  • Young Adult

Substances

  • DNA, Fungal