[Smoking--a risk factor for rheumatoid arthritis development]

Ugeskr Laeger. 2008 Sep 8;170(37):2864-9.
[Article in Danish]


Rheumatoid arthritis (RA) is a chronic disabling inflammatory joint disease of unknown aetiology. Genetic and environmental factors are implicated in its pathogenesis. We performed a literature search on MEDLINE, the Cochrane database and EMBASE on the interaction between smoking and RA. It is concluded that previous and current smoking constitute a risk factor for RA development. Smoking acts synergistically with other RA risk factors, including IgM-rheumatoid factor, anti-CCP and shared epitopes. The effect of smoking on the course of RA has not been described in sufficient detail.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Arthritis, Rheumatoid / etiology*
  • Arthritis, Rheumatoid / immunology
  • Disease Progression
  • Evidence-Based Medicine
  • Humans
  • Risk Factors
  • Severity of Illness Index
  • Smoking / adverse effects*