Correlation between IL-10 gene expression and HPV infection in cervical cancer: a mechanism for immune response escape

Cancer Invest. 2008 Dec;26(10):1037-43. doi: 10.1080/07357900802112693.


The present study was performed to determine IL-10 expression in cervical tissues in Mexican women according to the severity of the malignity and its association with HPV infection. IL-10 expression showed a clear tendency to increase during the different cervical cancer stages: 37% in LGSIL; 62% in HGSIL; and 84% in cancer. However, all the patients that expressed IL-10 were HPV positives; we found an association with HPV 16. These results suggest a clear relationship between IL-10, HPV and the stage of cervical cancer disease; this event could contribute to the immunosuppressive micro-environment in the tumor site.

MeSH terms

  • DNA Primers
  • DNA, Neoplasm / genetics
  • DNA, Neoplasm / isolation & purification
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Interleukin-10 / genetics*
  • Mexico
  • Neoplasm Staging
  • Papillomavirus Infections / complications*
  • Papillomavirus Infections / epidemiology
  • Papillomavirus Infections / immunology*
  • Prevalence
  • RNA, Messenger / genetics
  • RNA, Neoplasm / genetics
  • RNA, Neoplasm / isolation & purification
  • Reverse Transcriptase Polymerase Chain Reaction
  • Uterine Cervical Neoplasms / complications
  • Uterine Cervical Neoplasms / genetics*
  • Uterine Cervical Neoplasms / immunology
  • Uterine Cervical Neoplasms / pathology*


  • DNA Primers
  • DNA, Neoplasm
  • RNA, Messenger
  • RNA, Neoplasm
  • Interleukin-10