Mechanisms and consequences of dendritic cell migration

Immunity. 2008 Sep 19;29(3):325-42. doi: 10.1016/j.immuni.2008.08.006.


Dendritic cells (DCs) are critical for adaptive immunity and tolerance. Most DCs are strategically positioned as immune sentinels poised to respond to invading pathogens in tissues throughout the body. Differentiated DCs and their precursors also circulate in blood and can get rapidly recruited to sites of challenge. Within peripheral tissues, DCs collect antigenic material and then traffic to secondary lymphoid organs, where they communicate with lymphocytes to orchestrate adaptive immune responses. Hence, the migration and accurate positioning of DCs is indispensable for immune surveillance. Here, we review the molecular traffic signals that govern the migration of DCs throughout their life cycle.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Movement*
  • Chemotactic Factors / immunology
  • Chemotactic Factors / metabolism
  • Chemotaxis*
  • Cytokines / immunology
  • Cytokines / metabolism*
  • Dendritic Cells / immunology*
  • Dendritic Cells / physiology
  • Humans
  • Lymphoid Tissue / immunology*
  • Receptors, Chemokine / immunology
  • Receptors, Chemokine / metabolism
  • Signal Transduction
  • Spleen / cytology
  • Spleen / immunology


  • Chemotactic Factors
  • Cytokines
  • Receptors, Chemokine