Clenbuterol enhances the production of kynurenic acid in brain cortical slices and glial cultures

Pharmacol Rep. Jul-Aug 2008;60(4):574-7.

Abstract

The effect of a beta(2)-adrenergic agonist, clenbuterol on the production of a glutamate receptor antagonist, kynurenic acid was studied in vitro. Clenbuterol enhanced the production of kynurenic acid in brain cortical slices (0.1-1.0 mM) and in glial cultures (1-50 muM). Timolol, a non-selective beta-adrenergic antagonist prevented this effect. The presented data indicate a novel mechanism of action of beta(2)-adrenoceptor agonists and suggest that an increased formation of the endogenous glutamate receptor antagonist, kynurenic acid could partially contribute to their neuroprotective activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenergic beta-Agonists / pharmacology*
  • Animals
  • Cells, Cultured
  • Cerebral Cortex / drug effects*
  • Cerebral Cortex / metabolism*
  • Clenbuterol / pharmacology*
  • Excitatory Amino Acid Antagonists / metabolism*
  • In Vitro Techniques
  • Kynurenic Acid / metabolism*
  • Male
  • Neuroglia / drug effects*
  • Neuroglia / metabolism*
  • Rats
  • Rats, Wistar
  • Transaminases / metabolism

Substances

  • Adrenergic beta-Agonists
  • Excitatory Amino Acid Antagonists
  • Transaminases
  • kynurenine-oxoglutarate transaminase
  • Kynurenic Acid
  • Clenbuterol