[Why and how to assess hypospermia?]

Gynecol Obstet Fertil. 2008 Oct;36(10):1035-42. doi: 10.1016/j.gyobfe.2008.04.021. Epub 2008 Sep 17.
[Article in French]

Abstract

Hypospermia is a semen volume lower than 2 mL on at least two semen analyses. The etiologies of hypospermia are many and may be divided into two pathophysiologic sub-groups: disturbances of ejaculation reflex leading to partial retrograde ejaculation and seminal glands and ducts anatomic and functional anomalies. In this last pathologic mechanism, the mutations of CFTR gene, involved in many different forms of cystic fibrosis, represent a possible cause of hypospermia. The molecular anomaly of CFTR gene's screening is very important for the potential descendents and for the patient himself. It must be considered any time clinic and/or paraclinic context is evocative.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Cystic Fibrosis Transmembrane Conductance Regulator / genetics*
  • Ejaculation / physiology*
  • Genetic Testing
  • Humans
  • Male
  • Oligospermia / diagnosis
  • Oligospermia / etiology*
  • Oligospermia / genetics
  • Semen / physiology
  • Seminal Vesicles / abnormalities*
  • Sperm Count
  • Vas Deferens / abnormalities*

Substances

  • CFTR protein, human
  • Cystic Fibrosis Transmembrane Conductance Regulator