Molecular insights into mechanisms regulating faithful chromosome separation in female meiosis

Cell Cycle. 2008 Oct;7(19):2997-3005. doi: 10.4161/cc.7.19.6809. Epub 2008 Oct 18.


The faithful segregation of chromosomes into daughter cells in meiosis is crucial to produce healthy progeny. In gametogenesis, two consecutive rounds of chromosome separation occur with only one round of DNA replication, and the chromosome number is reduced to half to produce haploid gametes. Here, we discuss the molecular mechanisms underlying faithful chromosome separation in meiosis from three aspects: spindle checkpoint, two-step releases of cohesion, and the specific space-time protection of cohesin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle Proteins / metabolism
  • Chromosomal Proteins, Non-Histone / metabolism
  • Chromosome Segregation / physiology*
  • Female
  • Humans
  • Kinetochores / metabolism
  • Meiosis*
  • Models, Biological
  • Spindle Apparatus / physiology


  • Cell Cycle Proteins
  • Chromosomal Proteins, Non-Histone
  • cohesins