Function and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review series

EMBO Rep. 2008 Oct;9(10):969-76. doi: 10.1038/embor.2008.183. Epub 2008 Sep 19.


Neddylation is the post-translational protein modification that is most closely related to ubiquitination. However, ubiquitination is known to regulate a myriad of processes in eukaryotic cells, whereas only a limited number of neddylation substrates have been described to date. Here, we review the principles of protein neddylation and highlight the mechanisms that ensure the specificity of neddylation over ubiquitination. As numerous neddylation substrates probably remain to be discovered, we propose some criteria that could be used as guidelines for the characterization of neddylated proteins.

Publication types

  • Review

MeSH terms

  • Animals
  • Cullin Proteins / metabolism
  • Humans
  • NEDD8 Protein
  • Peptide Hydrolases / physiology
  • Protein Processing, Post-Translational / physiology*
  • Saccharomyces cerevisiae Proteins / metabolism
  • Ubiquitins / metabolism*


  • Cullin Proteins
  • NEDD8 Protein
  • NEDD8 protein, human
  • Nedd8 protein, mouse
  • RUB1 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Ubiquitins
  • Peptide Hydrolases