Although thickening of the gallbladder wall is a relatively frequent finding on diagnostic imaging studies, the condition has never been reported in patients with acute poststreptococcal glomerulonephritis (APSGN). We describe a patient with APSGN who presented with transient thickening of the gallbladder wall. While the precise pathogenic mechanism underlying this change in our patient was unclear, elevated systemic venous pressure or subclinical vasculitis may have caused edema of the gallbladder wall.