Pleural fluid findings as prognostic factors for malignant pleural mesothelioma

J Clin Lab Anal. 2008;22(5):334-6. doi: 10.1002/jcla.20266.


The aim of this study was to determine the prognostic value of pleural fluid glucose, lactate dehydrogenase (LDH), albumin, total protein, and total leukocyte levels in patients with malignant pleural mesothelioma. We retrospectively analyzed 71 consecutive patients (33 men and 38 women) who were referred to the department of chest diseases in a university hospital. Pleural fluid glucose levels, the ratio of pleural fluid to serum LDH>1.0, and total leukocyte count were significant predictors for the survival in univariate analysis. However, none of these variables emerged as statistically significant from the multivariate Cox model. In conclusion, our results showed that there is an inverse correlation between the intensity of inflammation and survival.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Albumins / analysis
  • Female
  • Glucose / analysis
  • Humans
  • L-Lactate Dehydrogenase / analysis
  • Male
  • Mesothelioma / chemistry
  • Mesothelioma / diagnosis*
  • Mesothelioma / mortality
  • Middle Aged
  • Pleural Effusion, Malignant / chemistry
  • Pleural Effusion, Malignant / diagnosis*
  • Pleural Effusion, Malignant / mortality
  • Prognosis
  • Proportional Hazards Models
  • Proteins / analysis
  • Retrospective Studies
  • Survival Rate


  • Albumins
  • Proteins
  • L-Lactate Dehydrogenase
  • Glucose