Neuregulin-1, a key axonal signal that drives Schwann cell growth and differentiation

Glia. 2008 Nov 1;56(14):1491-7. doi: 10.1002/glia.20753.

Abstract

Interactions between neuronal and glial cells are crucial for establishing a functional nervous system. Many aspects of Schwann cell development and physiology are regulated by neuronal signals; possibly the most spectacular is the elaboration of the myelin sheath. An extensive line of research has revealed that one neuronal factor, termed "neuregulin", promotes Schwann cell growth and survival, migration along the extending axon, and myelination. The versatility of glial responses elicited by this factor is thus clearly astounding.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Axons / metabolism*
  • Axons / ultrastructure
  • Cell Differentiation / physiology*
  • Cell Proliferation
  • Humans
  • Nerve Fibers, Myelinated / metabolism*
  • Nerve Fibers, Myelinated / ultrastructure
  • Neuregulin-1 / chemistry
  • Neuregulin-1 / genetics
  • Neuregulin-1 / metabolism*
  • Peripheral Nervous System / cytology
  • Peripheral Nervous System / embryology*
  • Peripheral Nervous System / growth & development
  • Protein Isoforms / chemistry
  • Protein Isoforms / genetics
  • Protein Isoforms / metabolism
  • Protein Structure, Tertiary / physiology
  • Schwann Cells / cytology
  • Schwann Cells / metabolism*
  • Signal Transduction / physiology

Substances

  • Neuregulin-1
  • Protein Isoforms