Molecular domains of myelinated axons in the peripheral nervous system

Glia. 2008 Nov 1;56(14):1532-40. doi: 10.1002/glia.20750.

Abstract

Myelinated axons are organized into a series of specialized domains with distinct molecular compositions and functions. These domains, which include the node of Ranvier, the flanking paranodal junctions, the juxtaparanodes, and the internode, form as the result of interactions with myelinating Schwann cells. This domain organization is essential for action potential propagation by saltatory conduction and for the overall function and integrity of the axon.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Action Potentials / physiology
  • Animals
  • Axons / physiology
  • Axons / ultrastructure
  • Cytoskeleton / metabolism
  • Humans
  • Nerve Fibers, Myelinated / physiology*
  • Nerve Fibers, Myelinated / ultrastructure
  • Nerve Tissue Proteins / metabolism
  • Neural Conduction / physiology
  • Peripheral Nervous System / cytology
  • Peripheral Nervous System / physiology*
  • Ranvier's Nodes / physiology
  • Ranvier's Nodes / ultrastructure
  • Schwann Cells / physiology*
  • Schwann Cells / ultrastructure

Substances

  • Nerve Tissue Proteins