Retinoic acid synthesis and signaling during early organogenesis
- PMID: 18805086
- PMCID: PMC2632951
- DOI: 10.1016/j.cell.2008.09.002
Retinoic acid synthesis and signaling during early organogenesis
Abstract
Retinoic acid, a derivative of vitamin A, is an essential component of cell-cell signaling during vertebrate organogenesis. In early development, retinoic acid organizes the trunk by providing an instructive signal for posterior neuroectoderm and foregut endoderm and a permissive signal for trunk mesoderm differentiation. At later stages, retinoic acid contributes to the development of the eye and other organs. Recent studies suggest that retinoic acid may act primarily in a paracrine manner and provide insight into the cell-cell signaling networks that control differentiation of pluripotent cells.
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References
-
- Ang HL, Deltour L, Hayamizu TF, Zgombic-Knight M, Duester G. Retinoic acid synthesis in mouse embryos during gastrulation and craniofacial development linked to class IV alcohol dehydrogenase gene expression. J. Biol. Chem. 1996;271:9526–9534. - PubMed
-
- Arnhold T, Tzimas G, Wittfoht W, Plonait S, Nau H. Identification of 9-cis-retinoic acid, 9,13-di-cis-retinoic acid, and 14-hydroxy-4,14-retro-retinol in human plasma after liver consumption. Life Sci. 1996;59:PL 169–PL 177. - PubMed
-
- Batourina E, Gim S, Bello N, Shy M, Clagett-Dame M, Srinivas S, Costantini F, Mendelsohn C. Vitamin A controls epithelial/mesenchymal interactions through Ret expression. Nature Genet. 2001;27:74–78. - PubMed
-
- Batourina E, Tsai S, Lambert S, Sprenkle P, Viana R, Dutta S, Hensle T, Wang FW, Niederreither K, McMahon AP, et al. Apoptosis induced by vitamin A signaling is crucial for connecting the ureters to the bladder. Nature Genet. 2005;37:1082–1089. - PubMed
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