Growing hyperbranched polyglycerols on magnetic nanoparticles to resist nonspecific adsorption of proteins

Shixing Wang; Yang Zhou; Shengchun Yang; Bingjun Ding

doi:10.1016/j.colsurfb.2008.08.009

Growing hyperbranched polyglycerols on magnetic nanoparticles to resist nonspecific adsorption of proteins

Colloids Surf B Biointerfaces. 2008 Nov 15;67(1):122-6. doi: 10.1016/j.colsurfb.2008.08.009. Epub 2008 Aug 22.

Authors

Shixing Wang¹, Yang Zhou, Shengchun Yang, Bingjun Ding

Affiliation

¹ Department of Materials Physics, School of Science, Xi'an Jiaotong University, Xi'an 710049, China. wsxkm@sina.com

PMID: 18805680
DOI: 10.1016/j.colsurfb.2008.08.009

Abstract

Hyperbranched polyglycerols were grown from magnetic nanoparticles (MNPs) via surface-initiated anionic ring-opening polymerization of glycidol. The modified MNPs were characterized by using TEM, XPS, TGA and FTIR. Hyperbranched polyglycerols resist the nonspecific adsorption of proteins on magnetic nanoparticles. The capability of hyperbranched polyglycerols is comparable favorably with the performance of methyloxy poly(ethylene glycol) (a linear mPEG with a molecular weight of 750) in resisting the adsorption of proteins.

Publication types

Comparative Study

MeSH terms

Adsorption / physiology
Glycerol / chemical synthesis*
Glycerol / chemistry
Magnetics*
Microscopy, Electron, Transmission
Nanoparticles / chemistry*
Nanoparticles / ultrastructure
Polymers / chemical synthesis*
Polymers / chemistry
Proteins / pharmacokinetics*
Spectroscopy, Fourier Transform Infrared

Substances

Polymers
Proteins
polyglycerol
Glycerol