Sequence of the Candida albicans gene encoding the secretory aspartate proteinase

J Med Vet Mycol. 1991;29(2):129-32.

Abstract

The gene encoding the Candida albicans aspartate proteinase that is secreted by cells grown in protein-containing media was cloned from a C. albicans genomic bank. The base sequence of the insert shows a 1173 bp open-reading frame and indicates an amino acid sequence typical of aspartate proteinases, with amino acid sequence homology to other enzymes of this class and a putative signal peptide consisting of 50 amino acids upstream of the active enzyme.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Aspartic Acid Endopeptidases / genetics*
  • Base Sequence
  • Candida albicans / enzymology
  • Candida albicans / genetics*
  • Cloning, Molecular
  • Culture Media
  • DNA, Fungal / chemistry*
  • Molecular Sequence Data
  • Oligonucleotide Probes
  • Open Reading Frames
  • Polymerase Chain Reaction
  • Protein Sorting Signals / genetics

Substances

  • Culture Media
  • DNA, Fungal
  • Oligonucleotide Probes
  • Protein Sorting Signals
  • Aspartic Acid Endopeptidases