Intentional ABO-incompatible lung transplantation

Am J Transplant. 2008 Nov;8(11):2476-8. doi: 10.1111/j.1600-6143.2008.02405.x. Epub 2008 Sep 19.


We report on a case of intentional blood group incompatible lung transplantation. A blood group O cystic fibrosis patient was mechanically ventilated and put on interventional lung assist for severe respiratory decompensation. Since timely allocation of a blood group O donor lung was impossible, an AB deceased donor lung rescue allocation was accepted and the transplant performed using a pre-, peri- and postoperative antibody depletion protocol including plasmapheresis, ivIg administration, rituximab and immunoadsorption. Nine months after the transplant the patient is at home and well.

Publication types

  • Case Reports

MeSH terms

  • ABO Blood-Group System / immunology*
  • Adsorption
  • Adult
  • Blood Group Incompatibility / immunology
  • Cystic Fibrosis / blood*
  • Cystic Fibrosis / therapy*
  • Female
  • Graft Survival
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Lung Transplantation / methods*
  • Plasmapheresis
  • Respiration, Artificial
  • Treatment Outcome


  • ABO Blood-Group System
  • Immunosuppressive Agents