Longitudinal changes in triglycerides according to ANGPTL4[E40K] genotype and longitudinal body weight change in the atherosclerosis risk in communities study

Ann Epidemiol. 2008 Nov;18(11):842-6. doi: 10.1016/j.annepidem.2008.07.004. Epub 2008 Sep 21.


Purpose: Allelic variation in the adipokine angiopoietin-like 4 gene (ANGPTL4[E40K]) has been cross-sectionally associated with triglycerides, but the effects of genotype, or the interaction between genotype and body weight, on longitudinal triglyceride change have not been studied.

Methods: Body weight, triglycerides, and ANGPTL4[E40K] genotype were determined at baseline (1987-1989) and at 3 follow-up exams (1990-1992, 1993-1995, 1996-1998) in 7,939 white ANGPTL4[E40K] G allele homozygotes and 344 A allele carriers. Changes in body weight and triglycerides were characterized as the difference between exam 4 and baseline measurements.

Results: ANGPTL4[E40K] A allele carriers had triglyceride concentrations that were 15 to 18 mg/dL lower than G allele homozygotes at all exams (P<0.0001). Triglycerides increased in both genotype groups over the 9-year period (+19.1+/-0.9 and +16.2+/-4.1 mg/dL in GG and GA/AA, respectively; P difference, 0.48). Weight gain was associated with increased triglycerides to a comparable degree in both genotype groups (+5.5+/-0.3 and +4.3+/-0.9 mg/dL per 2-kg increase in body weight in GG and GA/AA, respectively, p interaction=0.30).

Conclusions: Differences in triglyceride concentrations between ANGPTL4[E40K] A allele carriers and G allele homozygotes are maintained over time, but the degree of increase in triglycerides was similar between groups and was not modified by body weight changes.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Angiopoietin-like 4 Protein
  • Angiopoietins / genetics*
  • Atherosclerosis / blood
  • Atherosclerosis / genetics
  • Body Mass Index
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Risk Factors
  • Triglycerides / blood*
  • Triglycerides / genetics*
  • United States
  • Weight Gain / genetics*


  • ANGPTL4 protein, human
  • Angiopoietin-like 4 Protein
  • Angiopoietins
  • Triglycerides