Antifungal activities of human beta-defensins HBD-1 to HBD-3 and their C-terminal analogs Phd1 to Phd3

Antimicrob Agents Chemother. 2009 Jan;53(1):256-60. doi: 10.1128/AAC.00470-08. Epub 2008 Sep 22.

Abstract

The activities of defensins HBD-1, HBD-2, and HBD-3 and their C-terminal analogs Phd1, Phd2, and Phd3 against Candida albicans were investigated. Phd1 to Phd3 showed lower-level activities than HBD-1 to HBD-3, although metabolic inhibitors did not render Phd1 to Phd3 inactive. Their activities were also less salt sensitive than those of HBD-1 to HBD-3. Confocal microscope images indicated that the initial site of action was the fungal membrane.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacology*
  • Candida albicans / drug effects*
  • Humans
  • beta-Defensins / chemistry
  • beta-Defensins / pharmacology*

Substances

  • Antifungal Agents
  • DEFB1 protein, human
  • DEFB103A protein, human
  • beta-Defensins