Investigation of interaction between DCDC2 and KIAA0319 in a large German dyslexia sample

J Neural Transm (Vienna). 2008 Nov;115(11):1587-9. doi: 10.1007/s00702-008-0124-6. Epub 2008 Sep 23.


The dyslexia susceptibility locus DYX2 (chr. 6p21-p22) harbours two candidate genes, DCDC2 and KIAA0319. In 2006, Harold et al. reported evidence for interaction between both genes. Having previously identified a risk haplotype for dyslexia in DCDC2, but not KIAA0319, in German families, we also tested for interaction between this risk haplotype and KIAA0319. We found a nominally significant association for the quantitative dimension "word reading", the core phenotype in the study of Harold et al., which may be considered as supportive evidence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosomes, Human, Pair 6 / genetics
  • Dyslexia / epidemiology
  • Dyslexia / genetics*
  • Dyslexia / psychology*
  • Germany / epidemiology
  • Haplotypes
  • Humans
  • Linkage Disequilibrium / genetics
  • Microtubule-Associated Proteins / genetics*
  • Nerve Tissue Proteins / genetics*
  • Reading


  • DCDC2 protein, human
  • KIAA0319 protein, human
  • Microtubule-Associated Proteins
  • Nerve Tissue Proteins